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pentobarbital will reduce the extent or impact of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on into a lessen in fentanyl plasma concentrations, lack of efficacy or, perhaps, growth of the withdrawal syndrome within a